In 2011, Omeili began her acting career with the role of Debbie in "Behind the Smile" and later starred in her debut feature film "Married but Living Single." She's been part of various TV series, including "The Valley Between," "NESREA Watch," "Lekki Wives," and "Gidi Culture."

In 2011, she hosted the dance reality TV show "Dance 234." Omeili's role as Lovette in "Lekki Wives" was renewed for the second season in 2013. She gained acclaim for her portrayal in the 2016 Nigerian Box Office hit "Couple of Days."

In 2016, she produced her first short film, "Unprotected," based on true events from her time as a medical student. In 2018, Omeili started the production of her debut full-length feature film, "Run," which was released in 2019 and received recognition at international film festivals.

In 2023, Omeili joined the cast of MTV Shuga.